![]() ![]() Plasma His, Met, Trp, and taurine and whole blood taurine concentrations increased over the course of the study ( P 0.05). Data were analyzed using the GLIMMIX procedure with repeated measures in SAS (v. Fresh fecal samples were collected at weeks 0 and 26 for bile acid analyses. Urine was collected by free catch at weeks 0 and 26 for taurine and creatinine analyses. Fasted blood samples were collected prior to the start of the trial (baseline week 0) and at weeks 13 and 26 for analyses of blood chemistry, hematology, plasma amino acids, and whole blood taurine. Eight Labrador Retrievers (four males and four females Four Rivers Kennel, MO) were individually housed and fed a commercial complete and balanced grain-free diet (Acana Pork and Squash formula APS) for 26 wk. The objective of this study was to determine the effects of feeding a grain-free diet to large-breed dogs on taurine status and overall health. In some FDA case reports, but not all, dogs diagnosed with DCM also had low concentrations of plasma or whole blood taurine thus, we hypothesized that feeding these diets will result in reduced taurine status from baseline measures. However, all dog foods met regulatory minimums for nutrient inclusion recommended by the Association of American Feed Controls Official. In 2018, the Food and Drug Administration (FDA) released a statement that grain-free diets may be related to the development of canine dilated cardiomyopathy (DCM). Grain-free diets tend to have greater inclusions of pulses in contrast to grain-based diets. ![]()
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